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The usual starting dose for opioid naïve patients or patients presenting with severe pain uncontrolled by weaker opioids is 10 mg, 12-hourly. Some patients may benefit from a starting dose of 5 mg to minimise the incidence of side effects. The dose should then be carefully titrated, as frequently as once a day if necessary, to achieve pain relief. For the majority of patients, the maximum dose is 200 mg 12-hourly. However, a few patients may require higher doses. Doses in excess of 1000 mg daily have been recorded.

 

Increasing severity of pain will require an increased dosage of OxyContin tablets, using the 5 mg, 10 mg, 20 mg, 40 mg or 80 mg tablet strengths, either alone or in combination, to achieve pain relief. The correct dosage for any individual patient is that which controls the pain and is well tolerated for a full 12 hours. Patients should be titrated to pain relief unless unmanageable adverse drug reactions prevent this. If higher doses are necessary, increases should be made in 25% – 50% increments. The need for escape medication more than twice a day indicates that the dosage of OxyContin tablets should be increased.

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5 mg tablet contains 4.5 mg of oxycodone as 5 mg of oxycodone hydrochloride

10 mg tablet contains 9.0 mg of oxycodone as 10 mg of oxycodone hydrochloride

15 mg tablet contains 13.5 mg of oxycodone as 15 mg of oxycodone hydrochloride

20 mg tablet contains 18.0 mg of oxycodone as 20 mg of oxycodone hydrochloride

30 mg tablet contains 27 mg of oxycodone as 30 mg of oxycodone hydrochloride

40 mg tablet contains 36.0 mg of oxycodone as 40 mg of oxycodone hydrochloride

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Excipient with known effect:

4. Clinical particulars
4.1 Therapeutic indications

For the treatment of moderate to severe pain in patients with cancer and post-operative pain.

For the treatment of severe pain requiring the use of a strong opioid.

4.2 Posology and method of administration

Adults over 18 years:

OxyContin tablets should be taken at 12-hourly intervals. The dosage is dependent on the severity of the pain, and the patient’s previous history of analgesic requirements.

OxyContin is not intended for use as a prn analgesic.

 

Addiction & Withdrawal

Since oxycodone products should only be used based on a doctor’s prescription, signs of addiction
can be monitored and controlled more effectively than if the user is not under a physician’s care.
When used illicitly, the chances of becoming addicted to it increase exponentially.
Oxycodone, for example, has many similarities to other drugs of abuse including alcohol, heroin,
and marijuana, in that they elevate levels of dopamine, the neurotransmitter linked
with pleasure experiences.

 

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